Article
Sex differences in the relationship between estrogen receptor alpha gene polymorphisms and arterial stiffness in older humans.
American journal of hypertension - 1 Jun 2007
Hayashi Koichiro, Maeda Seiji, Iemitsu Motoyuki, Otsuki Takeshi, Sugawara Jun, Tanabe Takumi, Miyauchi Takashi, Kuno Shinya, Ajisaka Ryuichi, Matsuda Mitsuo
Abstract excerpt
BACKGROUND: Increased arterial stiffness is an independent risk factor for cardiovascular disease. The estrogen system (estrogen and estrogen receptor-alpha [ER-alpha]) has potent vasodilator and antiatherosclerotic activity in vascular tissue and therefore was implicated in the regulation of arterial stiffness. We hypothesized that the relationship between arterial stiffness and gene polymorphisms in ER-alpha...
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