Article
Effect of the gene dosage of CgammaP2C19 on diazepam metabolism in Chinese subjects.
Clinical pharmacology and therapeutics - 1 Dec 1999
Qin X P, Xie H G, Wang W, He N, Huang S L, Xu Z H, Ou-Yang D S, Wang Y J, Zhou H H
Abstract excerpt
OBJECTIVE: To determine whether the gene dosage of CYP2C19 affects the metabolism of diazepam and desmethyldiazepam in healthy Chinese subjects. SUBJECTS AND METHODS: Eighteen unrelated adult men were recruited for the study from a total of 101 healthy Chinese volunteers who had been screened for CYP2C19 phenotype and genotype. All subjects received a single oral dose (5 mg) of diazepam, and the pharmacokinetics...
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