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Article

Pharmacokinetics of citalopram in relation to genetic polymorphism of CYP2C19.

Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2003

Yu Bang-Ning, Chen Guo-Lin, He Nan, Ouyang Dong-Sheng, Chen Xiao-Ping, Liu Zhao-Qian, Zhou Hong-Hao

Abstract excerpt

The study was designed to define the contribution of cytochrome p450 2C19 (CYP2C19) and cytochrome p450 3A4 (CYP3A4) to citalopram N-demethylation and to evaluate the relationship between the disposition of citalopram and CYP2C19 genotype. A single oral 40-mg dose of citalopram was administered to eight extensive metabolizers and five poor metabolizers recruited from 77 healthy Chinese volunteers whose genotypes...

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Identifiers

PMID: 12975335
DOI: 10.1124/dmd.31.10.1255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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