Article
Cell-dependent replication potentials of HIV-1 gag mutants.
Microbes and infection - 1 Jul 1999
Adachi A, Tamaki M, Shimano R, Inubushi R, Naito T, Yoshida K, Oshima Y, Kawamura M, Koyama A H
Abstract excerpt
An infectious molecular clone of human immunodeficiency virus type 1 (HIV-1), designated pNLaiKH, which is tropic for both lymphocytic and monocytic cells, was constructed. To study the early function of HIV-1 Gag proteins in two types of cells, the mutations known to give host cell-dependent early defects were introduced into pNLaiKH, and the replication potentials and defective replication sites in the cells of...
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