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Article

Host cell-dependent replication of HIV-1 gag MA, CA, and NC mutants are independent of the functions of Vif and Vpu.

International journal of molecular medicine - 1 Jan 1999

Shimano R, Inubushi R, Adachi A

Abstract excerpt

We have previously shown that some gag gene mutants of human immunodeficiency virus type 1 (HIV-1) display a replication-defect in a cell-dependent manner. We and others have also demonstrated that the requirement of vif and vpu genes for HIV-1 replication is cell-dependent. To determine whether the cell-dependent growth of the HIV-1 gag mutants is related to the functions of Vif and Vpu, double mutants of...

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Identifiers

PMID: 9864392
DOI: 10.3892/ijmm.3.1.91

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