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Article

Integration of calcium and cyclic AMP signaling pathways by 14-3-3.

Molecular and cellular biology - 1 Jan 2000

Chow C W, Davis R J

Abstract excerpt

Calcium-stimulated nuclear factor of activated T cells (NFAT) transcription activity at the interleukin-2 promoter is negatively regulated by cyclic AMP (cAMP). This effect of cAMP is mediated, in part, by protein kinase A phosphorylation of NFAT. The mechanism of regulation involves the creation of a phosphorylation-dependent binding site for 14-3-3. Decreased NFAT phosphorylation caused by the...

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Identifiers

PMID: 10611249
DOI: 10.1128/MCB.20.2.702-712.2000
PMCID: PMC85175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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