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Article

Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.

Science (New York, N.Y.) - 28 Nov 1997

Chow C W, Rincón M, Cavanagh J, Dickens M, Davis R J

Abstract excerpt

The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells. NFAT activation is mediated in part by induced nuclear import. This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin. The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites. Mutational removal of the JNK phosphorylation...

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Identifiers

PMID: 9374467
DOI: 10.1126/science.278.5343.1638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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