Article
Requirement of two NFATc4 transactivation domains for CBP potentiation.
The Journal of biological chemistry - 26 Oct 2001
Yang T, Davis R J, Chow C W
Abstract excerpt
Recruitment of the coactivator CREB-binding protein (CBP) to transcription factors is important for gene expression. Various regions of CBP such as the KIX and CH3 domains have been shown to interact with numerous transcription factors. The NFAT group of transcription factors is involved in multiple biological processes. NFATc4/NFAT3 has been proposed to play an important role in heart hypertrophy, adipocyte...
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