Article
Possible association of CYP17 gene polymorphisms with the onset of rheumatoid arthritis.
Clinical and experimental rheumatology - 1 Jan 2000
Huang J, Ushiyama T, Inoue K, Mori K, Hukuda S
Abstract excerpt
OBJECTIVE: The etiologic role of sex hormones in rheumatoid arthritis (RA) has been discussed. Cytochrome P450c 17 alpha (CYP17) regulates steroidogenesis and the restriction fragment length polymorphisms (RFLPs) of the CYP17 gene are related to serum sex hormone production. In this study, the relationship between CYP17 gene RFLPs and RA was investigated. METHODS: Genomic DNA was extracted from the peripheral...
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