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Article

Structural basis of the transactivation deficiency of the human PPARγ F360L mutant associated with familial partial lipodystrophy.

Acta crystallographica. Section D, Biological crystallography - 1 Jul 2014

Lori Clorinda, Pasquo Alessandra, Montanari Roberta, Capelli Davide, Consalvi Valerio, Chiaraluce Roberta, Cervoni Laura, Loiodice Fulvio, Laghezza Antonio, Aschi Massimiliano, Giorgi Alessandra, Pochetti Giorgio

Abstract excerpt

The peroxisome proliferator-activated receptors (PPARs) are transcription factors that regulate glucose and lipid metabolism. The role of PPARs in several chronic diseases such as type 2 diabetes, obesity and atherosclerosis is well known and, for this reason, they are the targets of antidiabetic and hypolipidaemic drugs. In the last decade, some rare mutations in human PPARγ that might be associated with partial...

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PMID: 25004973
DOI: 10.1107/S1399004714009638

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