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Article

Cloning of polymorphisms (COP): enrichment of polymorphic sequences from complex genomes.

Nucleic acids research - 15 Jan 2000

Li J, Wang F, Zabarovska V, Wahlestedt C, Zabarovsky E R

Abstract excerpt

Here we describe a new procedure (cloning of polymorphisms, COP) for enrichment of single nucleotide polymorphisms (SNPs) that represent restriction fragment length polymorphisms (RFLPs). COP would be applicable to the isolation of SNPs from particular regions of the genome, e.g. CpG islands, chromosomal bands, YACs or PAC contigs. A combination of digestion with restriction enzymes, treatment with uracil-DNA...

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Identifiers

PMID: 10606669
DOI: 10.1093/nar/28.2.e1
PMCID: PMC102533

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