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Article

Targeted isolation of cloned genomic regions by recombineering for haplotype phasing and isogenic targeting.

Nucleic acids research - 1 Nov 2011

Nedelkova Marta, Maresca Marcello, Fu Jun, Rostovskaya Maria, Chenna Ramu, Thiede Christian, Anastassiadis Konstantinos, Sarov Mihail, Stewart A Francis

Abstract excerpt

Studying genetic variations in the human genome is important for understanding phenotypes and complex traits, including rare personal variations and their associations with disease. The interpretation of polymorphisms requires reliable methods to isolate natural genetic variations, including combinations of variations, in a format suitable for downstream analysis. Here, we describe a strategy for targeted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21852329
DOI: 10.1093/nar/gkr668
PMCID: PMC3203589

Genes

MECP2

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