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Article

High-resolution SNP mapping by denaturing HPLC.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2002

Nairz Knud, Stocker Hugo, Schindelholz Benno, Hafen Ernst

Abstract excerpt

With the availability of complete genome sequences, new rapid and reliable strategies for positional cloning become possible. Single-nucleotide polymorphisms (SNPs) permit the mapping of mutations at a resolution not amenable to classical genetics. Here we describe a SNP mapping procedure that relies on resolving polymorphisms by denaturing HPLC without the necessity of determining the nature of the SNPs. With...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12149455
DOI: 10.1073/pnas.162136299
PMCID: PMC124979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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