High-resolution SNP mapping by denaturing HPLC.

doi:10.1073/pnas.162136299

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Article

High-resolution SNP mapping by denaturing HPLC.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2002

Nairz Knud, Stocker Hugo, Schindelholz Benno, Hafen Ernst

Abstract excerpt

With the availability of complete genome sequences, new rapid and reliable strategies for positional cloning become possible. Single-nucleotide polymorphisms (SNPs) permit the mapping of mutations at a resolution not amenable to classical genetics. Here we describe a SNP mapping procedure that relies on resolving polymorphisms by denaturing HPLC without the necessity of determining the nature of the SNPs. With...

Topics

Animals
Chromatography, High Pressure Liquid
Chromosome Mapping
Drosophila
Female
Genes, Recessive
Male
Mutagenesis
Polymorphism, Single Nucleotide
Recombination, Genetic
ras Proteins

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Identifiers

PMID: 12149455
DOI: 10.1073/pnas.162136299
PMCID: PMC124979

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