Article
Etidronate inhibits the production of IL-6 by osteoblast-like cells.
Methods and findings in experimental and clinical pharmacology - 1 Oct 1999
Olmos J M, De Vega T, Perera L, Riancho J A, Amado J A, González-Macías J
Abstract excerpt
IL-6 is a resorbing cytokine synthesized by osteoblasts and monocytes that has been implicated in the pathogenesis of osteoporosis. Bisphosphonates are well-known antiresorptive drugs, the antiosteoclastic effect of which has been recently suggested to be brought about at least in part through osteoblasts. Based on these facts, we have studied the effect of etidronate on the production of IL-6 by two tumoral cell...
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