Article
SP500263, a novel SERM, blocks osteoclastogenesis in a human bone cell model: role of IL-6 and GM-CSF.
Cytokine - 1 Jul 2003
Kung Sutherland May S, Lipps Stephanie G, Patnaik Nandita, Gayo-Fung Leah M, Khammungkune Sak, Xie Weilin, Brady Helen A, Barbosa Miguel S, Anderson David W, Stein Bernd
Abstract excerpt
Bone metabolism requires tightly coupled activities exhibited by two unique cell populations, the bone-resorbing osteoclasts and the bone-forming osteoblasts. Imbalance in the function of these two cell types can result in osteoporosis, a condition characterized by loss in bone integrity and of bone mass. We developed a human bone cell culture model that allows the in vitro study of bone formation and...
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