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Article

Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line

1 Jan 2001

Abstract excerpt

Local growth of osteosarcoma involves destruction of host bone by proteolytic mechanisms and/or host osteoclast activation. Osteoclast formation and activity are regulated by osteoblast-derived factors such as the osteoclast differentiating factor, receptor activator of NF-kappaB ligand (RANKL) and the inhibitor osteoprotegerin (OPG). We have investigated the in vitro effects of bisphosphonates on a clonal rat...

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Identifiers

PMID: 11286476
DOI: 10.1054/bjoc.2000.1679

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Source receipt: pubmed, retrieved 7 Sept 2026.

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