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Article

Mitogenic responsiveness of human bone cells in vitro to hormones and growth factors decreases with age.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 1993

Pfeilschifter J, Diel I, Pilz U, Brunotte K, Naumann A, Ziegler R

Abstract excerpt

Bone loss with aging may at least in part be due to inadequate bone formation. In this study, we examined whether the proliferation of osteoblast-like cells in vitro in response to local and systemic factors might be attenuated with age. A total of 36 cultures of osteoblast-like cells were obtained from outgrowths of human trabecular bone. Parathyroid hormone, growth hormone, calcitonin, transforming growth...

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PMID: 8328313
DOI: 10.1002/jbmr.5650080609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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