Article
Mitogenic responsiveness of human bone cells in vitro to hormones and growth factors decreases with age.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 1993
Pfeilschifter J, Diel I, Pilz U, Brunotte K, Naumann A, Ziegler R
Abstract excerpt
Bone loss with aging may at least in part be due to inadequate bone formation. In this study, we examined whether the proliferation of osteoblast-like cells in vitro in response to local and systemic factors might be attenuated with age. A total of 36 cultures of osteoblast-like cells were obtain...
Topics
- Aged
- Aged, 80 and over
- Aging
- Calcitonin
- Cell Division
- Cells, Cultured
- DNA
- Female
- Growth Hormone
- Growth Substances
- Humans
- Insulin-Like Growth Factor I
- Middle Aged
- Osteoblasts
- Parathyroid Hormone
- Phenotype
- Platelet-Derived Growth Factor
- Transforming Growth Factor beta