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Article

Replication of linkage studies of complex traits: an examination of variation in location estimates.

American journal of human genetics - 1 Sept 1999

Roberts S B, MacLean C J, Neale M C, Eaves L J, Kendler K S

Abstract excerpt

In linkage studies, independent replication of positive findings is crucial in order to distinguish between true positives and false positives. Recently, the following question has arisen in linkage studies of complex traits: at what distance do we reject the hypothesis that two location estimates in a genomic region represent the same gene? Here we attempt to address this question. Sampling distributions for...

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Identifiers

PMID: 10441592
DOI: 10.1086/302528
PMCID: PMC1377992

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