Article
Accumulation of hRad9 protein in the nuclei of nonsmall cell lung carcinoma cells.
Cancer - 1 Jan 2005
Maniwa Yoshimasa, Yoshimura Masahiro, Bermudez Vladimir P, Yuki Takeshi, Okada Kenji, Kanomata Naoki, Ohbayashi Chiho, Hayashi Yoshitake, Hurwitz Jerard, Okita Yutaka
Abstract excerpt
BACKGROUND: DNA damage sensor proteins have received much attention as upstream components of the DNA damage checkpoint signaling pathway that are required for cell cycle control and the induction of apoptosis. Deficiencies in these proteins are directly linked to the accumulation of gene mutations, which can induce cellular transformation and result in malignant disease. METHODS: Using 48 sets of tumor tissue...
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