Article
Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A.
Molecular biology of the cell - 1 Jun 2008
Man Cornelia, Rosa Jack, Yip Y L, Cheung Annie Lai-Man, Kwong Y L, Doxsey Stephen J, Tsao S W
Abstract excerpt
The basic helix-loop-helix transcription factor, Id1, was shown to induce tetraploidy in telomerase-immortalized nasopharyngeal epithelial cells in this study. Using both transient and stable Id1-expressing cell models, multiple mitotic aberrations were detected, including centrosome amplification, binucleation, spindle defects, and microtubule perturbation. Many of these abnormal phenotypes have previously been...
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