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Article

Emergence and Evolution of Mutational Hotspots in Sun-Damaged Skin.

The Journal of investigative dermatology - 1 Jan 2018

Cheng Jeffrey B, Cho Raymond J

Abstract excerpt

In this issue, Albibas et al. investigate the mutational nature of p53-immunopositive patches, commonly observed in sun-damaged skin. p53-immunopositive patches have long been suspected to be lineal precursors to actinic keratoses and cutaneous squamous cell carcinomas. However, the mutations actually giving rise to p53-immunopositive patches, and their relationship to skin cancer, have never been defined. The...

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Identifiers

PMID: 29273145
DOI: 10.1016/j.jid.2017.09.007
PMCID: PMC6053279

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