Article
Inhibition of FGF signaling causes expansion of the endoderm in Xenopus.
Biochemical and biophysical research communications - 27 Feb 2004
Cha Sang-Wook, Hwang Yoo-Seok, Chae Jung-Pil, Lee Sung-Young, Lee Hyun-Shik, Daar Ira, Park Mae Ja, Kim Jaebong
Abstract excerpt
Fibroblast growth factor (FGF) is established as an initiator of signaling events critical for neurogenesis and mesoderm formation during early Xenopus embryogenesis. However, less is known about the role FGF signaling plays in endoderm specification. Here, we show for the first time that endoderm-specific genes are induced when FGF signaling is blocked in animal cap explants. This block of FGF signaling is also...
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