Article
An inducible system for the study of FGF signalling in early amphibian development.
Developmental biology - 1 Apr 2003
Pownall M E, Welm Bryan E, Freeman Kevin W, Spencer David M, Rosen Jeffrey M, Isaacs Harry V
Abstract excerpt
The use of a novel inducible FGF signalling system in the frog Xenopus laevis is reported. We show that the lipophilic, synthetic, dimerizing agent AP20187 is able to rapidly activate signalling through an ectopically expressed mutant form of FGFR1 (iFGFR1) in Xenopus embryos. iFGFR1 lacks an extracellular ligand binding domain and contains an AP20187 binding domain fused to the intracellular domain of mouse...
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