Article
The G972R variant of the insulin receptor substrate-1 (IRS-1) gene is associated with insulin resistance in "uncomplicated" obese subjects evaluated by hyperinsulinemic-euglycemic clamp.
Journal of endocrinological investigation - 1 Sept 2004
Baroni M G, Leonetti F, Sentinelli F, Romeo S, Filippi E, Fanelli M, Ribaudo M C, Zappaterreno A, Fallarino M, Di Mario U
Abstract excerpt
Several association studies have indicated the insulin receptor substrate-1 (IRS-1) gene G972R variant as a genetic risk factor for insulin resistance, particularly in presence of obesity. A few studies have also suggested a possible effect of the G972R variant on insulin secretion. The aim of this study was to evaluate the role of the IRS-1 gene G972R variant in 61 subjects with "uncomplicated" obesity [i.e....
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