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Article

Characterization of Candida albicans RNA triphosphatase and mutational analysis of its active site.

Nucleic acids research - 1 May 2000

Pei Y, Lehman K, Tian L, Shuman S

Abstract excerpt

The RNA triphosphatase component (CaCet1p) of the mRNA capping apparatus of the pathogenic fungus Candida albicans differs mechanistically and structurally from the RNA triphosphatase of mammals. Hence, CaCet1p is an attractive antifungal target. Here we identify a C-terminal catalytic domain of CaCet1p from residue 257 to 520 and characterize a manganese-dependent and cobalt-dependent NTPase activity intrinsic...

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Identifiers

PMID: 10756187
DOI: 10.1093/nar/28.9.1885
PMCID: PMC103306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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