Article

PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions

2019-12-20

Abstract excerpt

Expanded CAG nucleotide repeats are the underlying genetic cause of at least 14 incurable diseases, including Huntington’s disease (HD). The toxicity associated with many CAG repeat expansions is thought to be due to the translation of the CAG repeat to create a polyQ protein, which forms toxic oligomers and aggregates. However, recent studies show that HD CAG repeats undergo a non-canonical form of translation ca...

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Literature Corpus work: d47046d6-19ea-5f6c-8959-95eab532983b
DOI: 10.1101/2019.12.20.884254

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