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Article

RNAi for the large non-coding hsromega transcripts suppresses polyglutamine pathogenesis in Drosophila models.

RNA biology - 1 Jan 2000

Mallik Moushami, Lakhotia Subhash C

Abstract excerpt

Polyglutamine diseases are a class of inherited neurodegenerative disorders, characterized by expansion of CAG trinucleotide repeats translated into elongated glutamine tracts within the mutant proteins. Overexpression of the non-coding hsromega transcripts has been shown to dominantly enhance polyQ induced cytotoxicity in Drosophila. In the present study we demonstrate that RNA interference mediated...

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PMID: 19667761
DOI: 10.4161/rna.6.4.9268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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