Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Predicting the evolution of human influenza A.

Science (New York, N.Y.) - 3 Dec 1999

Bush R M, Bender C A, Subbarao K, Cox N J, Fitch W M

Abstract excerpt

Eighteen codons in the HA1 domain of the hemagglutinin genes of human influenza A subtype H3 appear to be under positive selection to change the amino acid they encode. Retrospective tests show that viral lineages undergoing the greatest number of mutations in the positively selected codons were the progenitors of future H3 lineages in 9 of 11 recent influenza seasons. Codons under positive selection were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigenic Variation
Share to Epitopes
Share to Forecasting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A virus

Share to Influenza, Human

Share to Probability

Source

Identifiers

PMID: 10583948
DOI: 10.1126/science.286.5446.1921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predicting the evolution of human influenza A.PMID 10583948Read ↗

The Wilhelmine E Key 1999 invitational lecture. Predicting the evolution of human influenza ASemantic proximity Read ↗

The variable codons of H3 influenza A virus haemagglutinin genes.Semantic proximity Read ↗

Positive selection on the H3 hemagglutinin gene of human influenza virus ASemantic proximity Read ↗

Codon bias and frequency-dependent selection on the hemagglutinin epitopes of influenza A virus.Semantic proximity Read ↗

Long term trends in the evolution of H(3) HA1 human influenza type ASemantic proximity Read ↗

The variable codons of H5N1 avian influenza A virus haemagglutinin genes.Semantic proximity Read ↗

Diversifying Selection Analysis Predicts Antigenic Evolution of 2009 Pandemic H1N1 Influenza A Virus in Humans.Semantic proximity Read ↗

Detection of positive selection eliminating effects of structural constraints in hemagglutinin of H3N2 human influenza A virus.Semantic proximity Read ↗

Positive selection on hemagglutinin and neuraminidase genes of H1N1 influenza virusesSemantic proximity Read ↗

Role of positive selection pressure on the evolution of H5N1 hemagglutinin.Semantic proximity Read ↗

Inference of genotype-phenotype relationships in the antigenic evolution of human influenza A (H3N2) viruses.Semantic proximity Read ↗

Dynamically correlated mutations drive human Influenza A evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.