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Article

Diversifying Selection Analysis Predicts Antigenic Evolution of 2009 Pandemic H1N1 Influenza A Virus in Humans.

Journal of virology - 1 May 2015

Lee Alexandra J, Das Suman R, Wang Wei, Fitzgerald Theresa, Pickett Brett E, Aevermann Brian D, Topham David J, Falsey Ann R, Scheuermann Richard H

Abstract excerpt

UNLABELLED: Although a large number of immune epitopes have been identified in the influenza A virus (IAV) hemagglutinin (HA) protein using various experimental systems, it is unclear which are involved in protective immunity to natural infection in humans. We developed a data mining approach analyzing natural H1N1 human isolates to identify HA protein regions that may be targeted by the human immune system and...

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Topics

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Share to Antigens, Viral
Share to Epitopes, B-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A Virus, H1N1 Subtype

Share to Influenza, Human

Share to Pandemics

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 25741011
DOI: 10.1128/JVI.03636-14
PMCID: PMC4442545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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