Article
Detection of positive selection eliminating effects of structural constraints in hemagglutinin of H3N2 human influenza A virus.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2013
Suzuki Yoshiyuki
Abstract excerpt
In the evolutionary studies of proteins, the average effect of natural selection operating on amino acid mutations may be examined by comparing the numbers of synonymous (dS) and nonsynonymous (dN) substitutions that have accumulated during the same time period. In this method, destabilizing muta...
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