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Article

Positive selection on the H3 hemagglutinin gene of human influenza virus A

1 Nov 1999

Abstract excerpt

The hemagglutinin (HA) gene of influenza viruses encodes the major surface antigen against which neutralizing antibodies are produced during infection or vaccination. We examined temporal variation in the HA1 domain of HA genes of human influenza A (H3N2) viruses in order to identify positively selected codons. Positive selection is defined for our purposes as a significant excess of nonsilent over silent...

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PMID: 10555276
DOI: 10.1093/oxfordjournals.molbev.a026057

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