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Article

Long term trends in the evolution of H(3) HA1 human influenza type A

22 Jul 1997

Abstract excerpt

We have studied the HA1 domain of 254 human influenza A(H3N2) virus genes for clues that might help identify characteristics of hemagglutinins (HAs) of circulating strains that are predictive of that strain's epidemic potential. Our preliminary findings include the following. (i) The most parsimonious tree found requires 1,260 substitutions of which 712 are silent and 548 are replacement substitutions. (ii) The...

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PMID: 9223253
DOI: 10.1073/pnas.94.15.7712

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