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Article

Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast.

Journal of cell science - 1 Aug 1997

Yamada H, Kumada K, Yanagida M

Abstract excerpt

We show here that the fission yeast gene products Cut9 and Nuc2 are the subunits of the 20S complex, the putative APC (anaphase promoting complex)/cyclosome which contains ubiquitin ligase activity required for cyclin and Cut2 destruction. The assembly of Cut9 into the 20S complex requires functional Nuc2, and vice versa. The size of fission yeast APC/cyclosome is similar to that of higher eukaryotes, but differs...

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PMID: 9264466
DOI: 10.1242/jcs.110.15.1793

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast.PMID 9264466Read ↗

Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses.Semantic proximity Read ↗

20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway.Semantic proximity Read ↗

Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization.Semantic proximity Read ↗

Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.Semantic proximity Read ↗

Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.Semantic proximity Read ↗

Cyclin-dependent kinase 1-dependent activation of APC/C ubiquitin ligase.Semantic proximity Read ↗

Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase.Semantic proximity Read ↗

Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis.Semantic proximity Read ↗

Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast.Semantic proximity Read ↗

Interaction of APC/C-E3 ligase with Swi6/HP1 and Clr4/Suv39 in heterochromatin assembly in fission yeast.Semantic proximity Read ↗

Characterization of the Apc10/Doc1 subunit of the anaphase promoting complex in Drosophila melanogaster.Semantic proximity Read ↗

FAM190A deficiency creates a cell division defect.Semantic proximity Read ↗

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