Article
Approaches to study GPCR regulation in native systems.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Willets Jonathon M
Abstract excerpt
The ability to assess whether individual proteins are involved in the signalling or regulation of G -protein-coupled receptor signalling is highly dependent on the pharmacological tools available. In the absence of appropriate pharmacological agents, alternative molecular approaches have been developed to alter either protein function or expression. This has included the use of mutants, for example catalytically...
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