Article
Functional inactivation of genes by dominant negative mutations.
Nature - 1 Jan 2000
Herskowitz I
Abstract excerpt
Molecular biologists are increasingly faced with the problem of assigning a function to genes that have been cloned. A new approach to this problem involves the manipulation of the cloned gene to create what are known as 'dominant negative' mutations. These encode mutant polypeptides that when ov...
Topics
- Animals
- Cloning, Molecular
- Genes
- Genes, Dominant
- Mutation
- Oncogenes
- RNA
- Recombination, Genetic
- Transcription Factors