Dominant negative mutants: tools for the study of protein function in vitro and in vivo.

doi:10.1165/ajrcmb.11.1.8018332

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Article

Dominant negative mutants: tools for the study of protein function in vitro and in vivo.

American journal of respiratory cell and molecular biology - 1 Jul 1994

Sheppard D

Abstract excerpt

Powerful new approaches for the identification and sequencing of novel cDNAs have produced a backlog of proteins seeking functions. Traditional approaches for characterizing protein function (e.g., blocking monoclonal antibodies and heterologous expression) have significant limitations, especiall...

Topics

Animals
Genetic Diseases, Inborn
Humans
Integrins
Lung
Mutagenesis
Mutation
Protein Engineering
Proteins
Receptors, Cell Surface

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