Dominant negative mutants: tools for the study of protein function in vitro and in vivo.

Abstract excerpt

Powerful new approaches for the identification and sequencing of novel cDNAs have produced a backlog of proteins seeking functions. Traditional approaches for characterizing protein function (e.g., blocking monoclonal antibodies and heterologous expression) have significant limitations, especially in identifying the roles specific proteins play in vivo. An alternative approach is to engineer mutations in the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic Diseases, Inborn
• Share to Integrins
• Share to Lung