Article
Interleukin-10 polymorphisms in Spanish multiple sclerosis patients.
Journal of neuroimmunology - 1 Oct 2002
Martinez Doncel Alfonso, Rubio Ana, Arroyo Rafael, de las Heras Virginia, Martín Carlos, Fernandez-Arquero Miguel, de la Concha Emilio G
Abstract excerpt
Interleukin-10 (IL-10) is an anti-inflammatory cytokine that may be an important regulator in multiple sclerosis (MS) pathogenesis. IL-10 gene contains three single nucleotide polymorphisms (SNPs) and two polymorphic microsatellites in the 5'-flanking region. Our aim was to ascertain if any of these polymorphic markers is associated or linked to MS among Spanish patients. We have genotyped 300 patients and 357...
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