Article
IL-10 gene promoter polymorphisms in rheumatoid arthritis.
Scandinavian journal of rheumatology - 1 Jan 1998
Hajeer A H, Lazarus M, Turner D, Mageed R A, Vencovsky J, Sinnott P, Hutchinson I V, Ollier W E
Abstract excerpt
IL-10 is an anti-inflammatory cytokine which may modulate disease expression in RA. Three dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression. The 1082*A allele has been associated with low and the 1082*G allele with high in vitro IL-10 production. We have analysed 117 unrelated Caucasoid RA patients and 119 ethnically matched...
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