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Interleukin 10 gene polymorphism in Iranian patients with multiple sclerosis.

Acta neurologica Taiwanica - 1 Jun 2010

Azarpira Negar, Borhani Haghighi Afshin, Pourjafar Mehrzad, Shariat Abdolhamid

Abstract excerpt

PURPOSE: IL-10 suppresses several activities of the immune response by inhibition of Th1 and Th2 cells. METHODS: We studied 110 Iranian patients with clinically definite multiple sclerosis (MS) and 100 ethnic and age matched controls. Three single-nucleotide polymorphisms in the proximal region of IL-10 promoter gene (-1082/-819/-592) were analysed by amplification refractory mutation system (ARMS) and polymerase...

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PMID: 20714960

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