Article
Genetic variation at position -1082 of the interleukin 10 (IL10) promotor and the outcome of multiple sclerosis.
Journal of neuroimmunology - 3 Apr 2000
Mäurer M, Kruse N, Giess R, Toyka K V, Rieckmann P
Abstract excerpt
Interleukin-10 is a potent immunomodulatory cytokine with possible implications for the pathogenesis of multiple sclerosis. Increased IL10 mRNA expression is associated with stable disease. The interleukin 10 gene is highly polymorphic and certain haplotypes result in differential interleukin-10 expression. The presence of guanine instead of adenine at position -1082 in the IL10 promotor was shown to result in a...
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