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Article

Functional implications of T cell receptor diversity.

Current opinion in immunology - 1 Jun 2009

Turner Stephen J, La Gruta Nicole L, Kedzierska Katherine, Thomas Paul G, Doherty Peter C

Abstract excerpt

Naive T cells are recruited into any given host response by recognizing a spectrum of possible antigens with 'sufficient' avidity. Does selecting a more functionally diverse array give better immune control? Perhaps low avidity 'killers' that 'kiss and run' operate optimally to eliminate virus-infected targets, while high avidity 'helpers' that stay faithfully in place produce more cytokine. Recent findings...

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Topics

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Share to Antigen-Presenting Cells
Share to Antigens, Viral
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes

Share to Virus Diseases

Source

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Identifiers

PMID: 19524428
DOI: 10.1016/j.coi.2009.05.004
PMCID: PMC2706259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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