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Article

Activation of growth hormone receptor delivers an antiapoptotic signal: evidence for a role of Akt in this pathway.

Endocrinology - 1 Dec 1999

Costoya J A, Finidori J, Moutoussamy S, Seãris R, Devesa J, Arce V M

Abstract excerpt

A signaling pathway was delineated by which GH promotes cell survival. Experiments were performed in human leukemic cells (HL-60) and Chinese hamster ovary (CHO) cells. In HL-60 cells, GH treatment reduced starvation-induced cell death. In contrast, when HL-60 cells were treated with an anti-GH antibody, cell survival was sharply reduced. In CHO cells stably expressing either the wild-type (wtGHR) or a truncated...

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Source

Identifiers

PMID: 10579361
DOI: 10.1210/endo.140.12.7209

Genes

GHR
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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