Article
Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5).
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2001
Friedrichsen B N, Galsgaard E D, Nielsen J H, Møldrup A
Abstract excerpt
GH and PRL stimulate proliferation and insulin production of pancreatic beta-cells. Whereas GH- and PRL-regulated transcription of the insulin gene in insulinoma cells has been shown to depend on STAT5 (signal transducer and activator of transcription 5), the signaling pathways involved in GH/PRL...
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