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Article

Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes

30 Mar 2007

Abstract excerpt

During systemic inflammation, the liver becomes unresponsive to growth hormone (GH), resulting in decreased plasma insulin-like growth factor-I (IGF-I) with concomitant reductions in lean body mass. Transgenic mice that overexpress IL-6 also demonstrate impaired growth and decreased IGF-I. To determine whether IL-6 directly inhibits GH-inducible gene expression, CWSV-1 hepatocytes were incubated with IL-6 (10...

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Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 17395896
DOI: 10.1152/ajpgi.00547.2006

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