Article
Mutation of a critical tryptophan to lysine in avidin or streptavidin may explain why sea urchin fibropellin adopts an avidin-like domain.
FEBS letters - 12 Nov 1999
Laitinen O H, Airenne K J, Marttila A T, Kulik T, Porkka E, Bayer E A, Wilchek M, Kulomaa M S
Abstract excerpt
Sea urchin fibropellins are epidermal growth factor homologues that harbor a C-terminal domain, similar in sequence to hen egg-white avidin and bacterial streptavidin. The fibropellin sequence was used as a conceptual template for mutation of designated conserved tryptophan residues in the biotin-binding sites of the tetrameric proteins, avidin and streptavidin. Three different mutations of avidin, Trp-110-Lys,...
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