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Article

Factors dictating the pseudocatalytic efficiency of avidins.

Journal of molecular biology - 5 May 2006

Prizant Maya, Eisenberg-Domovich Yael, Hytönen Vesa P, Kulomaa Markku S, Wilchek Meir, Bayer Edward A, Livnah Oded

Abstract excerpt

The hydrolysis of biotinyl p-nitrophenyl ester (BNP) by a series of avidin derivatives was examined. Surprisingly, a hyperthermostable avidin-related protein (AVR4) was shown to display extraordinary yet puzzling hydrolytic activity. In order to evaluate the molecular determinants that contribute to the reaction, the crystal structure of AVR4 was compared with those of avidin, streptavidin and key mutants of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16546211
DOI: 10.1016/j.jmb.2006.02.044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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