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Mouse Scarb2 Modulates EV-A71 Pathogenicity in Neonatal Mice

14 Jul 2022

Abstract excerpt

EV-A71 infects humans naturally but can also infect neonatal mice. The tissue tropism and severity of EV-A71 disease are determined by several factors, among which the virus receptor is thought to be important. We show that EV-A71 can infect neonatal mice using mScarb2. However, the infection efficiency of WT strains via mScarb2 is so low that an elevated virus-receptor interaction associated with mouse...

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PMID: 35867561
DOI: 10.1128/jvi.00561-22

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