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Identification of a Novel Virulence Factor in Recombinant Pneumonia Virus of Mice

14 Jun 2007

Abstract excerpt

Pneumonia virus of mice (PVM) is a murine relative of human respiratory syncytial virus (HRSV). Here we developed a reverse genetics system for PVM based on a consensus sequence for virulent strain 15. Recombinant PVM and a version engineered to express green fluorescent protein replicated as efficiently as the biological parent in vitro but were 4- and 12.5-fold attenuated in vivo, respectively. The G proteins...

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PMID: 17567693
DOI: 10.1128/jvi.00364-07

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