Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease.

Journal of virology - 1 Jan 2012

Frieman Matthew, Yount Boyd, Agnihothram Sudhakar, Page Carly, Donaldson Eric, Roberts Anjeanette, Vogel Leatrice, Woodruff Becky, Scorpio Diana, Subbarao Kanta, Baric Ralph S

Abstract excerpt

SARS coronavirus (SARS-CoV) causes severe acute respiratory tract disease characterized by diffuse alveolar damage and hyaline membrane formation. This pathology often progresses to acute respiratory distress (such as acute respiratory distress syndrome [ARDS]) and atypical pneumonia in humans, with characteristic age-related mortality rates approaching 50% or more in immunosenescent populations. The molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Reverse Genetics

Share to Severe Acute Respiratory Syndrome

Share to Severe acute respiratory syndrome-related coronavirus

Share to Viral Proteins

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 22072787
DOI: 10.1128/JVI.05957-11
PMCID: PMC3255850

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease.PMID 22072787Read ↗

Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human DiseaseSemantic proximity Read ↗

Characterization of Two Heterogeneous Lethal Mouse-Adapted SARS-CoV-2 Variants Recapitulating Representative Aspects of Human COVID-19Semantic proximity Read ↗

A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory miceSemantic proximity Read ↗

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challengeSemantic proximity Read ↗

A C57BL/6 Mouse Model of SARS-CoV-2 Infection Recapitulates Age- and Sex-Based Differences in Human COVID-19 Disease and RecoverySemantic proximity Read ↗

Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice.Semantic proximity Read ↗

Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.Semantic proximity Read ↗

A C57BL/6 Mouse model of SARS-CoV-2 infection recapitulates age- and sex-based differences in human COVID-19 disease and recoverySemantic proximity Read ↗

Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus InfectionSemantic proximity Read ↗

Engineering a mouse-adapted SADS-CoV and establishing a neonatal mouse model to study its infectionSemantic proximity Read ↗

Exploring the Biological Mechanisms of Severe COVID-19 in the Elderly: Insights from an Aged Mouse ModelSemantic proximity Read ↗

A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasuresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.