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Article

Cell Surface CD4 Inhibits HIV-1 Particle Release by Interfering with Vpu Activity

1 Nov 1999

Abstract excerpt

One of the hallmarks of human immunodeficiency virus type I (HIV-1) infection is the rapid removal of the viral receptor CD4 from the cell surface. This remarkably efficient receptor interference requires the activity of three separate viral proteins: Env, Vpu, and Nef. We have investigated whether this unusually tight interference on cell surface CD4 expression had a more essential function during the viral life...

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PMID: 10559275
DOI: 10.1074/jbc.274.47.33800

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